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目的 :研究雷米普利和氯沙坦对动脉粥样硬化 (atherosclerosis,AS)早期形成的影响。方法 :将 4 4只金黄地鼠随机分为 5组 ,分别给常规饲料 (对照组 )、高脂饲料 (含 10 %椰子油和 0 .0 5 %胆固醇 )、高脂饲料加雷米普利 (2mg·kg 1)、高脂饲料加氯沙坦 (10mg·kg 1)和高脂饲料加雷米普利 (2mg·kg 1)与氯沙坦 (10mg·kg 1)处理12周 ,测定血压、血脂、AS斑块面积和肝组织中胆固醇含量的变化。结果 :数据表明雷米普利和氯沙坦不论是单独应用还是联合应用均能有效降低平均动脉压 (P <0 .0 0 1)和肝组织中胆固醇的含量 ,雷米普利能显著降低血浆中甘油三酯的水平 (P <0 .0 5 ) ,结果还显示雷米普利与氯沙坦联合应用能提升血浆中高密度脂蛋白 (P <0 .0 5 ) ,各药物处理组的AS斑块面积有不同程度降低但无统计学意义。结论 :雷米普利与氯沙坦具有一定的抑制AS形成作用 ,其机制可能与降低血压和改变脂代谢有关。
Objective: To study the effects of ramipril and losartan on the early formation of atherosclerosis (AS). Methods: Forty-four golden hamsters were randomly divided into five groups, and fed with normal diet (control group), high fat diet (containing 10% coconut oil and 0.05% cholesterol), high fat diet plus ramipril (2mg · kg -1), high-fat diet plus losartan (10mg · kg -1) and high-fat diet plus ramipril (2mg · kg -1) and losartan (10mg · kg -1) Blood pressure, blood lipids, AS plaque area and changes of liver cholesterol content. RESULTS: The data showed that ramipril and losartan, both alone and in combination, were effective in reducing mean arterial pressure (P <.001) and cholesterol content in liver tissue, and ramipril significantly reduced plasma (P <0.05). The results also showed that combination of ramipril and losartan increased plasma high density lipoprotein (P <0.05), and that of AS Plaque area decreased to varying degrees but not statistically significant. Conclusion: Ramipril and losartan have a certain inhibitory effect on the formation of AS, the mechanism may be related to lowering blood pressure and altering lipid metabolism.