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目的探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者夜间不同时段发生呼吸暂停、低通气次数与心律失常次数及规律相关性。方法选择2006年5～12月在兰州大学第一医院就诊经多导睡眠图监测确诊的69例OSAHS男性患者,根据呼吸紊乱指数(AHI)分为轻度(16例)、中重度(52例)2组。收集其夜间不同时段发生呼吸暂停、低通气次数及心律失常次数和AHI、平均血氧饱和度(MSpO2)、最低血氧饱和度(LSpO2)。比较上述指标之间的差异并分析相互间的关系。结果OSAHS患者夜间不同时段发生呼吸暂停、低通气和心律失常次数有着明显的不同;中重度OSAHS患者在凌晨>3时至4时发生的呼吸暂停、低通气和心律失常次数明显高于其他时段(P<0.05),并与MSpO2和LSpO2呈负相关(P均<0.05);心律失常总次数与凌晨>3时至4时和>4时至5时发生的呼吸暂停、低通气次数呈线性回归关系(F=27.1,P=0.001)。结论中重度OSAHS患者夜间不同时段发生呼吸暂停、低通气次数和心律失常次数有着明显的规律性,尤其以凌晨>3时至4时为其高峰时段。
Objective To investigate the correlation between the number of apnea and the number of arrhythmias and the regularity of apnea in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) during different periods at night. Methods Sixty-nine OSAHS male patients diagnosed by polysomnography at the First Hospital of Lanzhou University from May 2006 to December 2006 were divided into mild (16 cases) and moderate-severe (52 cases) according to the respiratory disturbance index (AHI) )2 teams. The number of apnea, hypopnea, arrhythmia and AHI, mean arterial oxygen saturation (MSpO2), and minimum oxygen saturation (LSpO2) were collected at different time points during the night. Compare the differences between the above indicators and analyze the relationship between them. Results There were significant differences in the number of apnea, hypopnea and arrhythmia in patients with OSAHS at different time periods. The number of apnea, hypopnea and arrhythmia in patients with moderate-to-severe OSAHS was significantly higher than that in other periods P <0.05), and negatively correlated with MSpO2 and LSpO2 (all P <0.05). The total number of arrhythmia was linear regression with apnea and hypopnea frequency in the early morning> 3:00 to 4:00 and> 4:00 to 5:00 Relationship (F = 27.1, P = 0.001). Conclusions The patients with moderate-severe OSAHS have apnea, apnea-hypopnea and arrhythmia frequency at different time during nighttime, especially in the peak hours> 3:00 to 4:00.