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盐酸普鲁卡因是对氨基苯甲酸酯类局麻药。其结构不够稳定,受酸、碱及胆硷酯酶的影响均能水解为对氨基苯甲酸(简称PABA)及其它代谢产物。普鲁卡因静脉复合麻醉是我国常用的全麻方法之一。在临床应用中病人可出现高铁血红蛋白血症,现已被怀疑为血红蛋白被PA A及其生物转化产物所致。为探讨普鲁卡因及其代谢产物PABA与高铁血红蛋白形成的关系,我们开展了血清中普鲁卡因和PABA的含量测定,我们采用Ting在1949年报道的方法并进行了改进。实验证明:此法
Procaine hydrochloride is a para-aminobenzoate local anesthetic. Its structure is not stable enough, acid, alkali and cholinesterase can be hydrolyzed to p-aminobenzoic acid (PABA) and other metabolites. Procaine intravenous anesthesia is one of the commonly used method of general anesthesia in our country. Methemoglobinemia can occur in patients with clinical applications, has been suspected of hemoglobin PA A and its biotransformation products. In order to investigate the relationship between procaine and its metabolite PABA and methemoglobin, we performed a method for the determination of procaine and PABA in serum. We used the method reported by Ting in 1949 and made some improvements. Experimental proof: This method