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网状黄斑病变(RMD)是与年龄相关性黄斑变性(AMD)密切相关的一种独立的新型黄斑部疾病，目前通过多种新型的成像技术可对其做出诊断。共聚焦激光扫描检眼镜中的红外成像及频域光相干断层扫描对RMD诊断的敏感性和特异性最高，其成像特点与普通玻璃膜疣有着显著差别。RMD的发病原因与基因、环境、性别、年龄以及全身性疾病等有关，但具体的发病机制尚无定论，多项研究显示脉络膜血管病变与其密切相关，也有研究表明Bruch膜的病变可能是导致RMD典型表现网状假性玻璃膜疣首次出现的原因。RMD与晚期AMD，特别是干性地图状萎缩关系密切，也有部分RMD发展为晚期湿性AMD，早期干预有可能阻止其转变为晚期AMD的进程。近年来研究发现RMD与心血管疾病及部分恶性肿瘤相关，甚至有可能成为其预警标志。因此，对RMD的研究具有越来越重要的临床意义。本文就RMD发病特征、临床及影像学表现、视功能变化、与眼底及全身疾病的关系进行综述。“,”Reticular macular disease (RMD) is a novel, independent macular disease closely related to age-related macular degeneration (AMD). It is currently available to identify RMD through a variety of new imaging techniques.The infrared imaging in the confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography have the highest sensitivity and specificity for the diagnosis of RMD, and the imaging characteristics are significantly different from those of the common drusen.The cause of RMD has a certain correlation with genes, environment, gender, age and systemic diseases, but the specific pathogenesis is still inconclusive.Many studies showing that choroid vascular lesions are closely related, and Bruch membrane lesions may also be the cause of the first appearance of reticular pseudodrusen in some studies.RMD is closely related to advanced AMD, especially geographic atrophy, and some develop advanced wet-AMD.Early intervention may prevent its progression to advanced AMD.In recent years, it has been found to be associated with cardiovascular diseases and some malignant tumors, and may even become a warning sign.Therefore, research on RMD is of increasing importance in clinical implications.In this article, the characteristics of RMD, its clinical and imaging manifestations, changes of visual function and its relationship with fundus and systemic diseases were reviewed.