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目的:观察补肾中药二仙汤对2型糖尿病患者糖代谢及骨钙素的临床效果,并初步探讨二仙汤能否通过升高骨钙素来改善糖代谢。方法:在上海中医药大学附属曙光医院内分泌科招募适宜2型糖尿病患者60例,在固定原生活习惯及用药方案基础上,随机分组,治疗组加用二仙汤,对照组维持原用药方案,疗程为12周。观察糖化血红蛋白(Hb A1c),空腹血糖(FPG)、餐后血糖(PPG)、空腹C肽(FC-P)、胰岛素抵抗指数(HOMA2-IR)、胰岛β细胞功能(HOMA2-%β)、骨钙素、碱性磷酸酶、体重、体质指数(BMI)等指标。结果:治疗后各指标组间比较差异均无统计学意义;组内治疗前后比较:治疗组治疗后Hb A1c、PPG均有显著下降(P<0.01,P<0.05),HOMA2-%β有显著升高(P<0.05),骨钙素有升高趋势,但差异无统计学意义(P=0.067),其余指标以及对照组各指标与治疗前相比差异无统计学意义。结论:二仙汤对2型糖尿病患者血糖有一定的改善作用,但尚不能确定是否与骨钙素有关。
Objective: To observe the clinical effect of Bushen Chinese medicine Erxian decoction on glucose metabolism and osteocalcin in patients with type 2 diabetes mellitus, and to explore whether Erxian decoction could improve glucose metabolism by increasing osteocalcin. Methods: Sixty patients with type 2 diabetes were enrolled in Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. On the basis of the fixed original living habits and medication regimen, patients were randomly divided into treatment group and Erxian decoction group, and the control group was maintained with the original drug regimen. Treatment for 12 weeks. The levels of Hb A1c, FPG, FCG, FC-P, HOMA2-IR, HOMA2-% β, Osteocalcin, alkaline phosphatase, body weight, body mass index (BMI) and other indicators. Results: There was no significant difference between the two groups after treatment. The levels of Hb A1c and PPG were significantly decreased (P <0.01, P <0.05) and HOMA2-% β in the treatment group before and after treatment (P <0.05). However, there was no significant difference between the two groups (P = 0.067). There was no significant difference between the other indexes and the control group before treatment. Conclusion: Erxian decoction can improve blood glucose in type 2 diabetic patients, but it is not certain whether it is related to osteocalcin.