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1969年 Schaap 等首次发现,Mooren’s 角膜溃疡患者血中有循环角膜上皮抗体。后来,这一结果相继被其他作者所证实。但是,这种抗体是溃疡的原因,还是一种全身寄生虫或病毒感染的继发现象,至今尚不清楚。有人认为,这种循环抗体可能由眼前部炎症诱导产生,为了阐明这一问题,作者检测了葡萄膜炎患者和正常对照人的循环角膜上皮抗体,并讨论了这种抗体生成的可能机制。
Schaap et al. First found in 1969 that circulating corneal epithelial antibodies were present in Mooren’s corneal ulcer patients. Later, this result has been confirmed by other authors. However, it remains unclear whether this antibody causes ulcers or is a secondary phenomenon of systemic parasites or viral infections. It is believed that this circulating antibody may be induced by inflammation in the front of the eye. To elucidate this problem, the authors examined circulating corneal epithelial antibodies in uveitis patients and normal controls and discussed possible mechanisms for this antibody production.