基因治疗的策略主要有:(１)基因替换和基因补充,转换突变的癌基因或补充肿瘤细胞中缺失的抑癌基因;(２)基因导入以增强免疫效应细胞的抗癌效能。如:导入细胞因子基因和(或)免疫共刺激分子基因以增强免疫效应细胞的杀癌能力;(３)基因导入以增强肿瘤细胞的免疫原性,如:导入ＭＨＣＩ类抗原基因;(４)肿瘤药物敏感基因治疗——自杀基 Gene therapy strategies mainly include: (1) gene replacement and gene supplementation, conversion of mutated oncogenes or complementation of tumor suppressor genes deleted in tumor cells; (2) gene introduction to enhance the anti-cancer efficacy of immune effector cells. Such as: introduction of cytokine genes and (or) immune co-stimulatory molecular genes to enhance the ability of immune effector cells to kill cancer; (3) gene introduction to enhance the immunogenicity of tumor cells, such as: introduction of MHC class I antigen gene; (4) Cancer drug sensitive gene therapy - suicide-based