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肿瘤干细胞可能是肿瘤细胞多药耐药的罪魁祸首,它通过高表达ABC转运蛋白、抗凋亡蛋白等多种机制产生多药耐药性。与之相反,通过多种策略也可以逆转肿瘤干细胞的多药耐药性,杀死更多的肿瘤细胞。笔者就肿瘤干细胞的耐药机制及其逆转策略的近年研究做一综述。
Cancer stem cells may be the main culprit for multidrug resistance of tumor cells. It produces multidrug resistance through various mechanisms such as high expression of ABC transporters and anti-apoptotic proteins. In contrast, multiple strategies can also reverse the multidrug resistance of cancer stem cells and kill more tumor cells. The author reviewed the recent research on the mechanism of cancer stem cell resistance and its reversal strategy.