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异烟肼(INH)是常用的抗结核药。英国药典的1980年版规定INH片要作溶出速率试验,中国药典1977年版只规定作崩解度检查。本文按中国药典的方法测定了四个厂家生产的INH片的崩解度,并对三种释放度测定仪作了比较。从而对中国药典规定的崩解度检查法提出了建议。实验部分一、材料、仪器 INH:符合中国药典1977年版规定。盐酸:分析纯,配成N/10浓度。氢氧化钠:分析纯,配成N/1浓度。
Isoniazid (INH) is a commonly used anti-TB drug. The 1980 edition of the British Pharmacopoeia states that INH tablets should be tested for dissolution rate, and the Chinese Pharmacopoeia 1977 edition only provides for the disintegration test. In this paper, according to the method of Chinese Pharmacopoeia, the disintegration degree of INH tablets produced by the four manufacturers was determined, and the comparison of three kinds of release degree testers was made. Thus the Chinese Pharmacopoeial disintegration test method proposed. Experimental part A, materials, instruments INH: in line with the provisions of the Chinese Pharmacopoeia 1977 edition. Hydrochloric acid: analytical grade, dubbed N / 10 concentration. Sodium hydroxide: analytical grade, dubbed N / 1 concentration.