WWOX是公认的抑癌基因之一,与肿瘤坏死因子、p53蛋白及诸多其它信号通路蛋白相互作用而诱导细胞凋亡,同时WWOX的活性可被E2F-1、c-Jun氨基末端激酶1(JNK1)等因子调控。在肿瘤中WWOX失活主要是频发甲基化修饰、6~8外显子的丢失、LOH及WWOX蛋白表达的降低。增加该基因在肿瘤细胞和癌症患者中的表达将抑制肿廇的发生发展。目前该基因的信号通路过程还不明了,有待于进一步的研究。 WWOX, one of the well-recognized tumor suppressor genes, induces apoptosis by interacting with tumor necrosis factor, p53 protein and many other signaling pathways, and WWOX activity can be activated by E2F-1, c-Jun N-terminal kinase 1 (JNK1 ) And other factors regulation. In the tumor WWOX inactivation is mainly frequent methylation modification, 6 to 8 exon loss, LOH and WWOX protein expression decreased. Increasing the expression of this gene in tumor cells and cancer patients will inhibit the development of swollen lymph nodes. At present, the process of signal transduction of this gene is still unknown and needs further study.