Menin蛋白是MEN1基因的表达产物,MEN1是多发性内分泌肿瘤1型综合征(multiple endocrine neoplasia type1,MEN1)的关键致病基因之一。menin在细胞核中与其他关键转录因子相互作用,直接参与组蛋白甲基化修饰等基因表达调控过程。此外,menin在基因组稳定、细胞分裂增殖及细胞周期调控中都发挥着重要的作用,在肿瘤的发生和发展中扮演着重要的角色。全文对menin蛋白的生物学功能进展进行综述。 Menin protein is the expression product of MEN1 gene and MEN1 is one of the key pathogenes of multiple endocrine neoplasia type1 (MEN1). Menin interacts with other key transcription factors in the nucleus and is directly involved in the regulation of gene expression such as histone methylation. In addition, menin plays an important role in genomic stability, cell division, proliferation and cell cycle regulation, and plays an important role in tumorigenesis and development. The full text of the biological function of Menin protein are reviewed.