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目的：通过对我院抗菌药物临床应用专项整治活动的情况进行分析总结，找出存在的问题。提高抗菌药物合理应用水平，为后续管理提供依据。方法：采用回顾性调查法，统计出某院2013年10－14月与2014年4－6月两个阶段销售前10位的抗菌药物品种及消耗量（以DDDs表示），全院及各科室使用率、使用强度（每百人天DDDs值），不同管理级别抗菌药物DDDs，门诊、急诊抗菌药物处方比例，Ⅰ类切口、介入诊疗手术抗菌药物预防使用率等指标，并进行对比分析。结果：两阶段比较，后一阶段销售前10位抗菌药物品种比较合理，总DDDs下降。特别是哌拉西林钠他唑巴坦的DDDs显著下降，头孢哌酮钠舒巴坦没有进入前10位；全院抗菌药物使用率与使用强度全部达标。分别从66．52％、48．00％下降到44．32％、26．80％，大部分临床科室的3项指标同样有明显下降（P＜0．05）；非限制使用级抗菌药物DDDs显著下降（P＜0．05）；I类切口、介入诊疗术抗菌药物预防使用率，门诊、急诊抗菌药物处方比例呈显著下降趋势（P＜0．05），到2014年6月已全部达标（分别是20．14％，3．04％，18．25％，38．88％）。结论：经过一年多抗菌药物专项整治活动，我院抗菌药物各项监控指标得到了明显的控制，但是其临床应用尚存在某些不足，有待于进一步加强抗菌药物临床应用的管理。“,”Objective:are analyzed and summarized through the clinical use of antibacterial drugs special rectification activities in our hospital,find out the existing problems.To improve the level of rational use of antibacterial drugs,provide the basis for fol ow-up management.Methods:a retrospective investigation method,statistics of drug varieties and two stage of the sales from 2013 10-14 month and 4-6 months of 2014 the top 10 and the consumption of antibacterial (expressed as DDDs),the hospital and the department use rate,intensity of use(per hundred days DDDs value),the dif erent management levels of anti bacteria drugs DDDs,outpatient service,emergency antimicrobial prescription proportion,type I incision,interventional operation of preventive antibacterial utilization indicators,and carries on the contrast analysis.Results:the comparison of the two phase,a phase after the sales of the top 10 antibiotics reasonable,total DDDs decreased.Especial y of piperacil in sodium and tazobactam DDDs decreased significantly,cefoperazone sodium and Shubatan did not enter the top 10;the usage rate of antimicrobial a-gents and use the strength of al the standards.Respectively from 66.52%down to 44.32%,48%,26.80%,3 indicators most clinical departments also decreased significantly (P<0.05);the unrestricted use level ofantibacterial drugs DDDs decreased significantly (P<0.05);type I incision,interventional diagnosis and treatment of preventive antibacterial usage,outpatient and emergencyantimicrobial prescription proportion decreased significantly (P<0.05),to 2014 June has al the standard (respectively 20.14%,3.04%,18.25%,38.88%).Conclusion:after more than a year of antibacterial drugs special rectification activities,the monitoring indicators of antibiotics in our hospital were significantly control ed,but its clinical application stil existsome shortcomings,need to further strengthen the management of clinical use of antibacterial drugs.