【摘 要】
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BACKGROUND AND OBJECTIVEGabapentin and pregabalin are widely used in the United States, often for off-label indications. This study was designed to understand the change in gabapentinoid use from 2002
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BACKGROUND AND OBJECTIVEGabapentin and pregabalin are widely used in the United States, often for off-label indications. This study was designed to understand the change in gabapentinoid use from 2002 through 2015.
METHODSData for the study were obtained from the 2002-2015 Medical Expenditure Panel Survey, consisting of two, overlapping, noninstitutionalized, adult cohorts who self-reported medical conditions and health indicators. Medications recorded included gabapentinoids, benzodiazepines and opioids. Medical conditions were identified by self-report. Trends over time were calculated.
RESULTSSubjects were 346，177 adults. The percentage of individuals who used gabapentinoids increased from 1.2% in 2002 to 3.9% in 2015 (P<0.001). Of the gabapentinoids, gabapentin was used 82.6% of the time. A subgroup analysis revealed increases among individuals older than 64 years and among those with diabetes.
CONCLUSIONThis study found that the use of gabapentinoids in the United States more than tripled between 2002 and 2015.
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