人脑的发育需要一个相当长的时间,从胚胎期神经发生到出生后发育成拥有数百亿精确定位、高度特化、高度联系、细胞群集的复杂器官,在此期间每一发育阶段都必须有序、准时按期完成。胎儿期胎盘屏障和婴儿时期血脑屏障不能完全有效地阻挡化学物的暴露,使得神经系统发育早期如胚胎期、胎儿期和新生儿阶段更易受到环境神经毒物的影响。此类在神经系统发育阶段暴露于神经毒性物质后引起的神经系统结构和功能的异常性改变,即所谓的神经发育毒性 The development of the human brain takes a considerable amount of time to develop into complex organs with tens of billions of precisely localized, highly specialized, highly linked, cell clusters from the time of embryonic neurogenesis until after birth, during which time every phase of development must be Orderly, on time and on schedule. The Fetal Placental Barrier and the Infantile Blood-Brain Barrier do not completely block the exposure of chemicals, making the neurological development susceptible to environmental neurotoxicants early in life such as embryonic, fetal and neonatal stages. Such abnormalities in the structure and function of the nervous system caused by exposure to neurotoxic substances during the developmental stages of the nervous system, the so-called neurodevelopmental toxicity