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本文报道大鼠灌胃不同剂量(50—1000mg/kg)的8102和不同时间给药对~(234)Th 的促排效果。8102灌胃1000mg/kg 在2天内尿~(234)Th 排出量为对照组4.6倍;肝、骨、肾组织中蓄积量降低,分别为对照组蓄积量的30%、62%和68%。减少药物的剂量则效果降低。于注入~(234)Th 前1h 或2h 给药可提高促排效果,肝~(234)Th 蓄积量比立即给药组明显减少。延缓给药时间效果下降。文中对8102口服疗效的实用性进行了讨论。
In this paper, the effect of different doses (50-1000mg/kg) of 8102 and different doses of time on the promoting effect of ~(234) Th was reported. 8102 intragastric administration of 1000mg/kg urinary ~ (234) Th excretion in the 2 days as the control group 4.6 times; liver, bone, kidney tissue volume decreased, respectively, the control group volume 30%, 62% and 68%. Reducing the dose of the drug reduces the effect. Administration of 1 h or 2 h before the injection of ~(234)Th increased the effect of pro-drainage, and the amount of liver-(234)Th accumulation was significantly less than that of the immediate-administration group. The effect of delaying the administration time was reduced. The practicability of the oral efficacy of 8102 was discussed in this article.