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宫颈癌是导致妇女癌症死亡的第二大主要原因 ,90 %以上的宫颈癌与人乳头状瘤病毒 ( HPV)感染密切相关 ,其中最常见的病毒亚型是 HPV- 1 6 ,而 HPV- 1 6中的两种早期病毒基因 E6和 E7,在恶性表型的发生及维持方面起主要作用。作者采用两种表达 E7的肿瘤小鼠模型对重组 HPV- 1 6
Cervical cancer is the second leading cause of cancer death in women. More than 90% of cervical cancers are closely related to human papillomavirus (HPV) infection. The most common virus subtype is HPV-1 6 and HPV-1. The two early viral genes E6 and E7 in 6, play a major role in the occurrence and maintenance of malignant phenotypes. The authors used two tumor mouse models expressing E7 against recombinant HPV-1 6