原发性头痛发病率较高 ,药物治疗效果欠佳 ,存在不可避免的副反应 ,A型肉毒毒素的应用为原发性头痛的治疗提供了新方法。本文简要介绍A型肉毒毒素治疗原发性头痛 (包括偏头痛、紧张性头痛、丛集性头痛 )的研究进展及其治疗机制、安全性和远期效应 The high incidence of primary headache, poor efficacy of drug treatment, there is an unavoidable side effects, the application of botulinum toxin provides a new method for the treatment of primary headache. This article briefly describes the research progress and the mechanisms of treatment, safety and long-term effects of botulinum toxin type A in the treatment of primary headache (including migraine, tension headache, cluster headache)