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社会获得性肺炎是门诊患者就医的常见原因,部分患者需住院治疗;医院内肺炎是住院期间的严重并发症。常由对红霉素、氨苄青霉素和头孢菌素耐药的革兰氏阴性菌引起。已知老龄和COPD患者是发生下呼吸道感染的危险因素,预后较差,需早期快速诊断和治疗。及时用强有力的口服抗生素控制感染为患者最易接受的一种疗法。氟嗪酸(Ofloxacin)是一种新型喹诺酮类高效广谱抗菌药物,对肺炎链球菌、金黄色葡萄球菌、肺炎支原体、大肠杆菌和流感嗜血杆菌均有较强的杀菌活性。其最大的优点是口服后95％能被胃肠道吸收,血清浓度高,可作为静脉用药的替代药。观察住院的社会获得性肺炎87例,医院内肺炎13例,平均年龄57岁,基础病多为COPD、糖尿病和充血性心力衰竭,其中10例先前治疗失败。从以上患者
Social-acquired pneumonia is a common cause of outpatient medical care, and some patients require hospitalization; pneumonia in hospitals is a serious complication during hospitalization. Often caused by gram-negative bacteria resistant to erythromycin, ampicillin and cephalosporins. Age and COPD are known to be risk factors for lower respiratory tract infections and have a poor prognosis requiring early, rapid diagnosis and treatment. In a timely manner with a strong oral antibiotics to control infection for patients with the most acceptable treatment. Ofloxacin is a novel quinolone broad-spectrum antimicrobial drug with strong bactericidal activity against Streptococcus pneumoniae, Staphylococcus aureus, Mycoplasma pneumoniae, Escherichia coli and Haemophilus influenzae. Its biggest advantage is that 95% can be absorbed by the gastrointestinal tract after oral administration, with high serum concentration, which can be used as an alternative drug for intravenous drug use. Eighty-seven hospital-acquired social-acquired pneumonia and 13 hospital-acquired pneumonia were observed. The average age was 57 years. Most of the underlying diseases were COPD, diabetes and congestive heart failure. Of 10 cases, previous treatment failed. From the above patients