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目的通过小鼠试验,研究铁锌钙氨基酸白蛋白口服液对机体免疫功能的影响。方法运用淋巴器官/体重比值测定、半数溶血值测定、抗体生成细胞检测、碳廓清实验、ConA诱导的小鼠淋巴细胞转化实验、NK细胞活性测定、迟发变态反应实验、小鼠腹腔巨噬细胞吞噬鸡红细胞的能力实验,进行各项免疫指标的测定。结果给予小鼠不同剂量的铁锌钙氨基酸白蛋白口服液30d后,各剂量组体重增长与对照组相比,差异无统计学意义(P>0.05);小鼠的足跖肿胀度,各剂量组与对照组比较差异无统计学意义(P>0.05);各剂量组碳廓清功能,高剂量与阴性对照组比较差异有统计学意义(P<0.05);抗体生成细胞数及小鼠半数溶血值高剂量组与对照组比较差异均有统计学意义(P<0.05);各剂量组小鼠NK细胞活性,中、高剂量组与阴性对照组比较差异有统计学意义(P<0.05)。结论实验研究结果证实铁锌钙氨基酸白蛋白口服液具有增强免疫功能的作用。
Objective To study the effect of oral administration of Fe-Zn-Al-Amino Albumin on immune function in mice. Methods Lymphocyte / body weight ratio assay, hemolytic hemoglobin assay, antibody-producing cell assay, carbon clearance assay, ConA-induced mouse lymphocyte transformation assay, NK cell activity assay, delayed allergic reaction, mouse peritoneal macrophages The ability of phagocytosis of chicken erythrocytes experiments, the determination of various immune indicators. Results Compared with the control group, there was no significant difference in body weight gain between the three groups (P> 0.05) after 30d oral administration of different doses of Fe-Zn-Al-Albb albumin in mice. The mouse paw edema, There was no significant difference between the two groups (P> 0.05). The carbon clearance of each dose group was significantly higher than that of the negative control group (P <0.05). The number of antibody producing cells and half hemolytic (P <0.05). The activity of NK cells in each dose group was significantly lower than that in the control group (P <0.05). There was significant difference between the high dose group and the control group (P <0.05). Conclusions The experimental results confirm that the oral zinc-zinc-calcium amino acid albumin can enhance the immune function.