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目的：探讨Ｅ－钙粘素（Ｅ－ｃａｄｈｅｒｉｎ）和ｐ１６基因与鼻咽癌发生发展的关系。方法：采用免疫组化方法检测７４例鼻咽癌组织和２０例炎性鼻咽部组织中Ｅ－ｃａｄｈｅｒｉｎ和ｐ１６基因蛋白的表达。结果：炎性组织Ｅ－ｃａｄｈｅｒｉｎ和 ｐ１６显著高于鼻咽癌组织（ Ｐ＜ ０． ０５）； Ｅ－ｃａｄｈｅｒｉｎ和 ｐ１６保留表达与临床分期、病灶大小无关（ Ｐ＞ ０． ０５），但在颈淋巴结转移组显著低于无颈淋巴结转移组（Ｐ＜ ０．０５）。结论：本实验结果提示 Ｅ－ｃａｄｈｅｒｉｎ和 ｐ１６基因可能与鼻咽癌的转移潜能有关，其确切作用有待于进一步研究。
Objective: To investigate the relationship between E-cadherin and p16 gene and the occurrence and development of nasopharyngeal carcinoma. Methods: The expressions of E-cadherin and p16 protein in 74 cases of nasopharyngeal carcinoma and 20 cases of inflammatory nasopharyngeal tissues were detected by immunohistochemistry. Results: The expressions of E-cadherin and p16 in inflammatory tissues were significantly higher than those in nasopharyngeal carcinoma (P <0.05). The expressions of E-cadherin and p16 were not correlated with the clinical stage and the size of the lesion (P> 0.05) Lymph node metastasis was significantly lower than those without cervical lymph node metastasis (P <0.05). Conclusion: The results of this study suggest that E-cadherin and p16 may be involved in the metastatic potential of nasopharyngeal carcinoma. The exact role remains to be further studied.