慢性病毒性肝炎的长期迁延与肝纤维化的发生和发展关系密切。据统计,全球约有3.5亿人患慢性乙型肝炎,约1.7亿人患慢性丙型肝炎。此类感染者中约20%～30%会发生肝纤维化。此外,非酒精性脂肪肝患者也随2型糖尿病而增多,这也与肝硬化的发生有关。肝纤维化的实验室诊断指标向来是临 Chronic viral hepatitis and long-term liver fibrosis occurrence and development are closely related. According to statistics, about 350 million people in the world suffer from chronic hepatitis B and about 170 million people suffer from chronic hepatitis C. About 20% to 30% of those infected will develop liver fibrosis. In addition, patients with non-alcoholic fatty liver also increased with type 2 diabetes, which is also related to the occurrence of cirrhosis. Laboratory diagnosis of liver fibrosis has always been an indicator