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炎症性肠病是慢性且易反复发作的胃肠道病症,主要包括溃疡性结肠炎和克罗恩病。Occludin蛋白是肠紧密连接中最重要的蛋白质分子之一,表达上调,可以减少肠上皮受损,保护肠黏膜上皮间的紧密连接蛋白,降低肠道通透性[1]。美沙拉秦因其疗效好及不良反应较少而作为溃疡性结肠炎的一线治疗药,但仍可见其不良反应。蒙脱石散是良好的肠黏膜保护剂,参与肠黏膜的直接修复作用。本研究测定肠紧密连接occludin蛋白,拟评价美沙拉秦和蒙脱石散单独或联
Inflammatory bowel disease is a chronic and recurrent gastrointestinal disorder that mainly includes ulcerative colitis and Crohn’s disease. Occludin protein is one of the most important protein molecules in intestinal tight junctions. Upregulation of Occludin protein can reduce the damage of intestinal epithelium, protect the tight junction protein between intestinal mucosa epithelium and reduce intestinal permeability [1]. Mesalazine is regarded as the first-line treatment for ulcerative colitis because of its good curative effect and less adverse reactions, but its adverse reactions can still be seen. Montmorillonite powder is a good intestinal mucosal protective agent, involved in the direct repair of intestinal mucosa. This study determined the intestine tight junctions occludin protein, to be evaluated mesalamine and montmorillonite powder alone or linked