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1957年研究者发现了一种能干扰病毒在宿主细胞增殖的蛋白质,即干扰素(Interferon,IFN),分为I型干扰素和Ⅱ型干扰素两大类。I型IFN家族包括IFN-α,IFN-β[1]。IFN-α和IFN-β的分子有序列同源性,共用相同的细胞表面受体,并且有类似的功能。Ⅱ型IFN又称为免疫干扰素或γ-干扰素(I
In 1957, the researchers discovered a protein that interferes with the virus’s proliferation in host cells, namely Interferon (IFN), which is classified into two major types, Type I and Type II. Type I IFN families include IFN-α, IFN-β [1]. The molecules of IFN-α and IFN-β have sequence homology, share the same cell surface receptors, and have similar functions. Type II IFN, also known as immune interferon or interferon (I