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建立大鼠动静脉旁路插管溶栓模型 ,评价QP6A的溶栓作用。方法 :用尿激酶的溶栓作用验证该溶栓模型的可靠性 ,用生理盐水 (3ml·kg-1)作空白对照 ,用尿激酶 (2 0 0 0 0IU·kg-1)作阳性对照 ,在该模型上评价了QP6A(10 μmol·kg-1)的溶血栓作用。结果 :给药 1h后 ,尿激酶组血栓减重 (13± 5 )mg ,QP6A组血栓减重 (9± 6 )mg ,二者与生理盐水组血栓减重 (0 .8± 7 0 )mg相比差异有显著性。 结论 :该溶栓模型在药物研究中可用于活性评价 ,QP6A有望成为一种新的溶栓药物。
Establishment of rat arteriovenous bypass intubation thrombolysis model, evaluation of QP6A thrombolytic effect. Methods: The thrombolytic effect of urokinase was used to verify the reliability of the thrombolysis model. Normal saline (3ml · kg-1) was used as a blank control and urokinase (20 000 IU · kg-1) as a positive control. The thrombolytic effect of QP6A (10 μmol · kg-1) was evaluated on this model. Results: Thrombus weight loss (13 ± 5) mg in the urokinase group and 9 ± 6 mg in the QP6A group were significantly lower than those in the saline group (0.8 ± 0.7) mg Compared with the difference was significant. Conclusion: This model of thrombolysis can be used for activity evaluation in drug research. QP6A is expected to become a new thrombolytic drug.