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Objective:To observe the efficacy and the side effects of nedaplatin with futraful in the treatment of advanced esophageal carcinoma. Methods:Observing group NDP/FT-207 regimen:given nedaplatin 80-100 mg/m2 on day 1 and futraful 500-600 mg/m2 on day 1 to 5;control group:DDP/5-Fu regimen received cisplatin 80-100 mg/m2 on day 1 and 5-Fluorouracil 500-750 mg/m2 on day 1 to 5. In both groups per 28 days was a cycle, 2-3 cycles were one course. Results:Response and toxicity could be assessed in all the 78 patients, 42 patients were in observing group, the other 36 patients were in control group. The response rate of patients treated by NDP/FT-207 and DDP/5-Fu were 57.1% (24/42) and 50% (18/36) respectively. The two groups have no significant difference. The toxicities as gastrointestinal disorders and myelosuppression in observing group was lighter than those in control group. Conclusion:The combination of NDP and FT-207 is a safer and effective regimen.