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目的比较小剂量垂体后叶素加心痛定与生长抑素治疗肝硬化曲张静脉破裂出血的有效性和安全性。方法２９例垂体后叶素加心痛定治疗者，先以垂体后叶素１０ｕ稀释静注，继以每小时１．６～１．７ｕ静滴４８小时，再依次每小时静滴 １．２～ １．３，０．８～０．８５和０．４～０．４５ｕ各２４小时。同时每６小时舌下含服心痛定 １０ｍｇ。 １７例生长抑素治疗者，先静注生长抑素１００ｕｇ，继以每小时１０～１２，６～８和４ｕｇ分别连续静滴４８，２４和４８小时。结果在４８小时内，全组总出血控制率为７６％，其中垂体后叶素加心痛定治疗组为８６％，高于生长抑素治疗组的５８％（Ｐ＜０．０１）。停药后一周再出血率分别为前者的８％和后者的３０％（Ｐ＜０．０５）。两组均未见明显副反应。结论小剂量垂体后叶素加心痛定可有效地治疗肝硬化曲张静脉破裂出血，优于生长抑素，且副反应小，价格低，使用方便，适合各级医疗单位临床应用。
Objective To compare the efficacy and safety of low dose of vasopressin with xintongding and somatostatin in the treatment of cirrhosis varicose vein hemorrhage. Methods 29 cases of pituitrin plus xintongding treatment, pituitrin 10u dilute the first intravenous injection, followed by intravenous infusion of 1.6 ~ 1.7u per hour 48 hours, and then followed by intravenous infusion of 1.2 ~ 1.3, 0.8 ~ 0.85 and 0.4 ~ 0.45u each 24 hours. At the same time every 6 hours sublingual convulsion given 10mg. 17 cases of somatostatin treatment, first intravenous somatostatin 100ug, followed by continuous intravenous infusion of 10 ~ 12,6 ~ 8 and 4ug 48, 24 and 48 hours. Results Within 48 hours, the overall rate of total bleeding control was 76%. The pituitrin plus xintongding treatment group was 86%, which was higher than that of the somatostatin treatment group (58%, P <0.01). The rate of rebleeding one week after discontinuation was 8% for the former and 30% for the latter (P <0.05). No obvious side effects in both groups. Conclusion The low dose of vasopressin plus xintong decoction can effectively treat cirrhosis and variceal hemorrhage, which is superior to somatostatin, and has the advantages of low side reaction, low price and convenient operation, and is suitable for clinical application at all levels of medical units.