22例肿瘤化疗患者采用随机对照交叉试验 ,对照组采用单纯化疗实验组采用化疗 +双歧杆菌活菌制剂。结果显示双歧杆菌活菌制剂可预防化疗引起的腹泻 (对照组腹泻率 45 .5 % ,实验组为 2 7.3% ) ,并可改善腹泻的反应程度 (重度腹泻率对照组为 18.2 % ,实验组为 4.5 % ) ,有统计学差异 (P<0 .0 1) ,提示双歧杆菌活菌制剂预防化疗引起的腹泻疗效确切。 Twenty-two patients with cancer chemotherapy were randomized controlled crossover trials, while the control group was treated with chemotherapy alone and chemotherapy plus bifidobacteria. The results showed that bifidobacteria viable agents can prevent chemotherapy-induced diarrhea (diarrhea rate in the control group was 45.5%, and the experimental group was 27.3%) and could improve the degree of diarrhea reaction (heavy diarrhea rate in the control group was 18.2%. The group was 4.5%) and there was a statistical difference (P<0.01), suggesting that the efficacy of the bifidobacteria viable agents in preventing chemotherapy-induced diarrhea was definitive.