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目的:分析克林霉素预防性治疗对妊娠期B族溶血性链球菌感染患者的临床疗效。方法:选取2015年9月—2016年2月期间确诊治疗的妊娠期B族溶血性链球菌感染患者46例,依据随机分配原则将其分为防治组和对照组,每组23例;对照组患者均给予常规治疗(如助产、引产等),防治组患者在对照组基础上给予克林霉素预防性治疗,分析两组患者治疗后胎膜早破、早产及宫内感染、产褥感染、新生儿感染等情况。结果:防治组患者治疗后胎膜早破和早产的发生率明显低于对照组(P<0.05),总感染的发生率明显低于对照组(P<0.05)。结论:克林霉素用于预防性治疗能有效改善妊娠期B族溶血性链球菌感染患者的母婴结局,降低母婴疾病感染的发生率。
Objective: To analyze the clinical efficacy of clindamycin prophylaxis in patients with B-streptococcal infection during pregnancy. Methods: Forty-six patients with B-streptococcal infection during pregnancy diagnosed from September 2015 to February 2016 were selected and randomly divided into control group and control group, 23 cases in each group. The control group Patients were given conventional treatment (such as midwifery, induction of labor, etc.), prevention and treatment group on the basis of the control group to give clindamycin preventive treatment, analysis of two groups of patients after treatment of premature rupture of membranes, premature delivery and intrauterine infection, puerperal Infection, neonatal infection and so on. Results: The incidence of premature rupture of membranes and premature labor in patients in control group was significantly lower than that in control group (P <0.05). The incidence of total infection was significantly lower than that in control group (P <0.05). Conclusion: Clindamycin can be used in prophylactic treatment to improve the maternal and infant outcomes of patients with B-streptococcal infection during pregnancy and reduce the incidence of maternal and infant diseases.