胶质瘤是颅内常见恶性肿瘤 ,传统治疗方法包括手术切除、放疗和化疗的效果及潜力有限 ,病人预后极差。随着对胶质瘤发病机制的深入研究 ,新的治疗方式基因治疗已广泛用于胶质瘤治疗的试验和临床研究。本文就近年国内外对胶质瘤基因治疗研究的几个方面作一简要综述 Glioma is a common intracranial malignant tumor, the traditional treatment methods, including surgical resection, radiotherapy and chemotherapy, the effect and potential is limited, the patient’s prognosis is poor. With the in-depth study of the pathogenesis of glioma, the new treatment of gene therapy has been widely used in glioma treatment of experimental and clinical studies. This article reviews several aspects of gene therapy of glioma at home and abroad in recent years to make a brief review