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饮水中有机污染物的日益增加已引起人们的普遍关注。因此,研究饮水中有机提取物的致突变性,具有十分重要的意义。以往国内外对综合评价饮水中有机提取物遗传毒性的报道较少。本试验意在提供对饮水中有机提取物遗传毒性的综合评价。 1 材料与方法 1.1 试验动物与受试物:本校实验动物中心繁殖的昆明种小鼠,体重22～26g,SCE试验用24只小鼠,雌雄各半,随机分为3组,分别为中浓度组(57μg/kg)、高浓度组(570μg/kg)和阴性对照组二甲基亚砜(DMSO)。
The increasing concentration of organic pollutants in drinking water has caused widespread concern. Therefore, it is of great significance to study the mutagenicity of organic extracts in drinking water. In the past, there have been few reports on comprehensive evaluation of the genetic toxicity of organic extracts in drinking water. This trial is intended to provide a comprehensive assessment of the genotoxicity of organic extracts in drinking water. 1 Materials and Methods 1.1 Test Animals and Test Subjects: Kunming mice, breeding at the Experimental Animal Center of our school, weighing 22-26 g, 24 mice for SCE test, half male and half female, randomly divided into 3 groups, respectively, in the medium concentration The group (57 μg/kg), the high concentration group (570 μg/kg) and the negative control group dimethyl sulfoxide (DMSO).