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心肌成纤维细胞和肌纤维母细胞增生直接促进心脏的重塑及机能改变,最终导致收缩性和/或舒张性的心力衰竭。心肌营养素-1属IL-6超家族；是迄今发现的IL-6家族中最强的体外诱导心肌细胞肥大因子。近来发现其与心肌梗死后心肌的成肌纤维细胞增殖、成纤维细胞增生和胶原分泌有关。心肌营养素-1可能在心肌梗死后心室重塑起着重要作用。
Myocardial fibroblasts and myofibroblastic proliferation directly promote cardiac remodeling and functional changes, eventually leading to contractile and / or diastolic heart failure. Cardiotrophin-1 is an IL-6 superfamily; it is the strongest in vitro inducing cardiomyocyte hypertrophy factor in the IL-6 family so far found. Recently found that myocardial infarction with myocardial myofibroblasts proliferation, fibroblast proliferation and collagen secretion related. Cardiotrophin-1 may play an important role in ventricular remodeling after myocardial infarction.