自1970年以来,由于显带技术的使用,关于ph~1染色体的研究逐渐深入。本文将近年来关于ph~1染色体研究的新动态作一简要介绍。Ph~1染色体的性质1970年Caspersson 等采用Q 带才首先证明ph~1染色体系22号染色体长臂的部分缺失,即22q-。1973年有人同时使用Q 带和G 带终于明确ph~1染色体的性质是22号和9号染色体长臂间的平衡易位,t(9;22)(q34;p11),而不是缺失。慢性粒细胞白血病(慢粒)患者中,9;22易位占94%,故这一易位称为典型的或标准的Ph~1易位。最近有人发现22号长臂的断裂事实上可发生于长臂的任何部位,因而导致Ph~1染色体的多形性。他们 Since 1970, due to the use of the banding technique, the research on the ph ~ 1 chromosome has been progressively studied. In this paper, the recent developments on ph ~ 1 chromosomes are briefly introduced. Nature of Ph ~ 1 Chromosomes were first demonstrated by Caspersson et al. (1970) in the Q band before the partial deletion of the long arm of chromosome 22 in the ph ~ 1 chromosome, 22q-. The simultaneous use of the Q band and the G band by some in 1973 finally made it clear that the nature of the ph ~ 1 chromosome was the equilibrium translocation between the long arms of chromosomes 22 and 9, t (9; 22) (q34; p11) rather than absent. In chronic myeloid leukemia (CML) patients, 9,22 translocations accounted for 94%, so this translocation is called a typical or standard Ph-1 translocation. Recently, it has been found that the 22 # long arm fracture can in fact occur in any part of the long arm, resulting in Ph ~ 1 chromosome polymorphism. they