论文部分内容阅读
胍(R1~NHC(=NR~2)NHR~3)为一类独特的三氮化合物,其结构单元广泛存在于天然产物和药物分子中.他们具有多样性生物活性,在药物和农药领域都有广泛应用;此外,其在有机合成和功能材料领域也有很高的应用价值.由于胍独特的结构和广泛的应用价值,其合成方法的研究已成为有机合成研究的一个热点.近年来不断有胍的新合成方法涌现,特别是高效的过渡金属催化合成方法.本文主要对近20年来发展的过渡金属催化构筑C—N键反应合成胍类化合物的方法进行综述,全面介绍各类胍化合物合成方法的研究现状,总结归纳不同过渡金属催化合成方法的规律、特点及不足,为过渡金属催化合成胍类化合物的研究提供帮助.
As a unique triazolate, guanidine (R1 ~ NHC (= NR ~ 2) NHR ~ 3) has a wide range of structural units in natural products and drug molecules. They possess diverse biological activities, both in the fields of pharmaceuticals and pesticides It is also widely used in the fields of organic synthesis and functional materials.Due to the unique structure and wide application value of guanidine, the synthesis of guanidine has become a hot research topic in organic synthesis.In recent years, The new synthetic methods of guanidine are emerging, especially the efficient transition metal catalytic synthesis method.In this paper, the synthesis of guanidine compounds catalyzed by transition metal catalyzed by C-N bond in recent 20 years is reviewed, and the synthesis of various guanidine compounds Methods, and summarized the laws, characteristics and shortcomings of different transition metal catalyzed synthesis methods, and provided help for the research on the transition metal-catalyzed synthesis of guanidine compounds.