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新生大鼠吸吮饮用含Pb~(2+)300 ppm和1000ppm水的母鼠乳汁(约含Pb~(2+)10～25ppm)连续21 d后,血铅和脑铅含量有显著增高,其血和脑ALAD活性亦有不同程度的抑制,说明Pb~(2+)容易由母体乳汁传递给新生大鼠引起铅中毒。另外还看到,新生大鼠脑匀浆、脑线粒体和微粒体的膜MDA含量及脂质过氧化荧光物质量比对照明显增加,血浆SOD活性抑制,均提示Pb~(2+)引起膜损伤(一是促进膜脂质过氧化作用;二是抑制SOD活性),因而出现Pb~(2+)对中枢神经系统的神经毒性。
Newborn rats suck drinking breast milk (containing Pb ~ (2+) 10 ~ 25ppm) containing Pb2 + 300ppm and 1000ppm water for 21 days continuously, the content of blood lead and brain lead significantly increased Blood and brain ALAD activity also have different degrees of inhibition, indicating that Pb ~ (2+) is easily passed from the mother’s milk to neonatal rats lead poisoning. In addition, it was also observed that the content of MDA and the content of lipid peroxidation phosphorescence in neonatal rat brain homogenates, brain mitochondria and microsomes were significantly increased compared with the control, and the plasma SOD activity was inhibited, both of which suggested that Pb 2+ induced membrane damage (One is to promote membrane lipid peroxidation; the other is to inhibit the activity of SOD), which leads to the neurotoxicity of Pb 2+ on the central nervous system.