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氟卡胺的发现始于1966年,通过氟原子取代氢原子等一系列化学方法及动物实验筛选,使具有局部麻醉特性的分子改造成一种抗心律不齐新药。在1972年由ELden Banitt合成氟卡胺,1975年首次用于健康志愿者,1978年试用于病人,直至1982年由美国食品和药物管理局批准作为新药应用。作用机制与电生理效应: 氟卡胺(乙酸氟卡胺,Flecainide acetate)其化学结构如下:
The discovery of flecainide began in 1966, through a series of chemical methods such as fluorine atoms instead of hydrogen atoms and animal experiments screening, so that the molecules with local anesthetic characteristics into a new anti-arrhythmia drugs. Flecainide was synthesized by ELden Banitt in 1972, was first used in healthy volunteers in 1975, and was tested in patients in 1978 until approved by the U.S. Food and Drug Administration as a new drug in 1982. Mechanism of action and electrophysiological effects: Flecainide (Flecainide acetate) its chemical structure is as follows: