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目的提高晚期血吸虫病(晚血)合并HBV感染患者抗病毒治疗的疗效,减少并发症,提高生活质量。方法选择2003年2月至2012年12月在作者所在医院行抗病毒治疗的27例腹水型晚血合并HBV感染患者作为治疗组,对其抗HBV治疗的临床及随访资料进行回顾性分析;同时以31例未作抗乙肝病毒治疗、病情基本相同的腹水型晚血合并HBV感染患者作为对照。结果治疗组自发性腹膜炎、肝性脑病、肝肾综合征、上消化道出血、原发性肝癌的发生率明显低于对照组,肝功能、肾功能、凝血酶原时间检测指标明显优于对照组,死亡率明显低于对照组。结论腹水型晚期血吸虫病合并HBV感染患者通过抗病毒治疗,可明显改善患者愈后,提高患者生存率。
Objective To improve the efficacy of anti-virus therapy in patients with advanced schistosomiasis (late blood) and HBV infection, reduce complications and improve quality of life. Methods 27 patients with HBV-infected patients with ascites in the hospital from February 2003 to December 2012 were selected as the treatment group. The clinical and follow-up data of anti-HBV therapy were retrospectively analyzed. At the same time, Thirty-one cases of HBV-infected patients with ascites and no HBV infection who were treated with anti-HBV were divided into two groups. Results The incidence of spontaneous peritonitis, hepatic encephalopathy, hepatorenal syndrome, upper gastrointestinal bleeding and primary liver cancer in the treatment group was significantly lower than that in the control group. The indexes of liver function, renal function and prothrombin time were significantly better than those of the control group Group, the mortality rate was significantly lower than the control group. Conclusions Ascites-type patients with advanced schistosomiasis complicated with HBV infection can significantly improve the prognosis of patients and improve their survival rate after antiviral treatment.