Objective:To determine the relationship between asymptomatic malaria parasitemia and some oxidative stress parameters in pregnant Nigerian women.Methods:This is a cross-sectional study involving 130 normal pregnant women at various trimesters,who were attending antenatal clinic at the University of Nigeria Teaching Hospital(UNTH) and Kenechukwu Specialist Hospital in Enugu.A comparable group(control),made of 30 non pregnant women was also recruited.After a 24 hour dietary recall,serum levels of vitamin A,C and malondialdehyde(MDA) were determined by colorimetric method,while vitamin E was determined by absorptiometric method.Results:There were no statistically significant differences in age,parity,estimated calorie,vitamins A,C and E intake between the pregnant and non pregnant groups(P>0.05).The serum level of the vitamins(umol/L) and MDA(umol/L) in control,1st,2nd and 3rd trimesters respectively were:(l)Vitamin A:1.6±0.36 vs 0.6±0.26 vs 0.62±0.33 vs 0.46±0.21(P<0.0001);(2) Vitamin C:75.65±14.15 vs 62.97±24.4 vs 37.85±15.19 vs 28.94±8.52(P<0.0001);(3) Vitamin E:3.01±1.32 vs 3.45±2.01 vs 9.36±2.75 vs 9.82±2.97(P<0.0001);(4) MDA:1.42±0.02 vs 1.61±0.02 vs 1.79±0.02 vs 2.03±0.05(P<0.0001).However,there were no significant changes in the serum level of the vitamins and MDA between the positive and the negative parasitemia subjects(P>0.05). Conclusions:Asymptomatic malaria parasitemia does not induce additional oxidative stress on pregnant women in Nigeria.The enormity of acute and complicated attack should be further investigated. Objective: To determine the relationship between asymptomatic malaria parasitemia and some oxidative stress parameters in pregnant Nigerian women. Methods: This is a cross-sectional study involving 130 normal pregnant women at various trimesters, who were attending antenatal clinic at the University of Nigeria Teaching Hospital (UNTH) and Kenechukwu Specialist Hospital in Enugu. A comparable group (control), made of 30 non-pregnant women was also recruited. After a 24 hour dietary recall, serum levels of vitamin A, C and malondialdehyde (MDA) were determined by colorimetric method, while vitamin E was determined by absorptiometric method. Results: There were no statistically significant differences in age, parity, estimated calorie, vitamins A, C and E intake between the pregnant and non-pregnant groups (P> 0.05). serum levels 1st and 2nd trimesters were: (1) Vitamin A: 1.6 ± 0.36 vs 0.6 ± 0.26 vs 0.62 ± 0.33 vs 0.46 ± 0.21 (P <0.0001); (2) Vitami n C: 75.65 ± 14.15 vs 62.97 ± 24.4 vs 37.85 ± 15.19 vs 28.94 ± 8.52 (P <0.0001); (3) Vitamin E: 3.01 ± 1.32 vs 3.45 ± 2.01 vs 9.36 ± 2.75 vs 9.82 ± 2.97 (P <0.0001) ; (4) MDA: 1.42 ± 0.02 vs 1.61 ± 0.02 vs 1.79 ± 0.02 vs 2.03 ± 0.05 (P <0.0001). There was no significant changes in the serum level of the vitamins and MDA between the positive and the negative parasitemia subjects (P> 0.05). Conclusions: Asymptomatic malaria parasitemia does not induce additional oxidative stress on pregnant women in Nigeria. The enormity of acute and complicated attack should be further investigated.