早在1992年Skolnick等在人类第九号染色体寻找黑素瘤易感基因时,发现9P21位点频发缺失与突变,后来Kamb及Beach分别领导的两个科研小组通过对多种癌细胞的普查,发现了一个新的能抑制多种肿瘤的基因——P16基因,P16基因,又称MTS1(Multiple Tumor Suppressor 1),或称INK4a(Inhibitor of Cyclin—dependent Kinase 4a),目前被认为是唯一直接作用于细胞周期的抑瘤基 When Skolnick et al. searched for a melanoma susceptibility gene on chromosome 9 of humans in 1992, he discovered frequent deletions and mutations in the 9P21 site. Later, two research teams led by Kamb and Beach passed a survey of various cancer cells. A new gene that inhibits multiple tumors has been discovered - the P16 gene, P16 gene, also known as MTS1 (Multiple Tumor Suppressor 1), or INK4a (Inhibitor of Cyclin-dependent Kinase 4a), is currently considered the only direct Anti-tumor base acting on cell cycle