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目的 探讨畅脉舒防治动脉粥样硬化 (AS)的作用机制。方法 采用高胆固醇饲料喂养 ,建立家兔 AS模型 ,随机分为对照组、模型组、地奥心血康组 (地奥组 )和畅脉舒用药组 ,每组在实验第 1 4周取血标本测定血脂、血清一氧化氮 (NO)、血浆内皮素 (ET)、环鸟苷酸 (c GMP)、脂质过氧化物 (L PO)和超氧化物歧化酶 (SOD)等指标。结果 与模型组比较 ,畅脉舒及地奥组 1 3周后均能提高 NO,c GMP,高密度脂蛋白 (HDL - C)含量和 SOD活性 (P<0 .0 5 ,P<0 .0 1 ) ,降低ET,L PO,L DL - C、甘油三酯 (TG)、总胆固醇 (TC)和低密度脂蛋白 (L DL - C)含量 (P<0 .0 1 ) ,并且在降低 ET和 L PO,升高NO,c GMP含量及 SOD活性方面优于地奥心血康组 (P<0 .0 5 )。结论 畅脉舒可以有效地降低血脂 ,减少动脉粥样硬化斑块形成 ,是防治动脉粥样硬化有效的复方中药制剂。
Objective To investigate the mechanism of Chang Mai Shu on atherosclerosis (AS). Methods A high-cholesterol diet was used to establish the AS model of rabbits and randomly divided into control group, model group, Diao Xinxuekang group (Diao group) and Changmaishu medication group. Each group took blood samples to determine blood lipids at the 14th week of the experiment. Serum nitric oxide (NO), plasma endothelin (ET), cyclic guanosine monophosphate (c GMP), lipid peroxide (L PO) and superoxide dismutase (SOD) and other indicators. Results Compared with the model group, Changmaishu and Di’ao group could increase NO, c GMP, high density lipoprotein (HDL-C) content and SOD activity after 13 weeks (P<0.05, P<0.01). ), decreased ET, L PO, L DL -C, triglyceride (TG), total cholesterol (TC), and low density lipoprotein (L DL -C) levels (P < 0.01), and decreased ET And LPO, elevated NO, c GMP content and SOD activity were superior to Dioxinxuekang group (P<0.05). Conclusion Changmaishu can effectively reduce blood lipids and reduce atherosclerotic plaque formation. It is an effective compound traditional Chinese medicine preparation for prevention and treatment of atherosclerosis.