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目的分析氯氮平致癫痫发作的临床特征,为合理使用氯氮平,预防癫痫发作提供依据。方法对我院1989～1996年间住院服用氯氮平的临床资料进行整理、分析。结果 1274例病人服用氯氮平中23例病人发生癫痫发作,发生率为1.81％。结论癫痫发作是氯氮平的严重副反应之一,临床医生应为此倍加重视,以减少癫痫发作频率。
Objective To analyze the clinical characteristics of clozapine-induced seizures and provide evidences for the rational use of clozapine in preventing seizures. Methods The clinical data of inpatients taking clozapine from 1989 to 1996 in our hospital were collected and analyzed. Results Seizures occurred in 23 of the 1274 patients taking clozapine, with an incidence of 1.81%. Conclusion Epileptic seizures are one of the serious side effects of clozapine. Clinicians should pay more attention to this to reduce the frequency of seizures.