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目的:研究2型糖尿病(T2DM)患者血浆总同型半胱氨酸(tHcy)水平的变化及与糖尿病肾病(DN)的关系。方法:将109例2型糖尿病患者分为正常蛋白尿组(A组,42例)、微量蛋白尿组(B组,36例)和大量蛋白尿组(C组,31例)3组,分别检测其血浆tHcy水平,并与对照组(78例)比较。结果:与对照组比较,T2DM患者血浆tHcy水平显著升高(P<0.01)。B组、C组与A组比较及B组与C组比较,tHcy均升高,差异有统计学意义(P<0.01)。T2DM患者tHcy水平的升高与尿白蛋白排泄率(UAER)呈正相关(r=0.389,P<0.01)。结论:T2DM患者的tHcy水平升高,并随着肾脏损害的加重而逐步升高。tHcy水平增高可能是糖尿病肾病的一个新的危险因素。
Objective: To study the changes of plasma total homocysteine (tHcy) and its relationship with diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). Methods: 109 patients with type 2 diabetes were divided into three groups: normal proteinuria group (group A, n = 42), microalbuminuria group (group B, n = 36) and mass proteinuria group The level of plasma tHcy was measured and compared with the control group (78 cases). Results: Compared with the control group, plasma tHcy levels were significantly increased in T2DM patients (P <0.01). The levels of tHcy in group B, group C and group A were significantly higher than those in group C (P <0.01). The level of tHcy in T2DM patients was positively correlated with urinary albumin excretion (UAER) (r = 0.389, P <0.01). Conclusions: The level of tHcy in T2DM patients increases and increases gradually with the increase of renal damage. Increased tHcy levels may be a new risk factor for diabetic nephropathy.