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目的探讨生态营养对急性胃黏膜损伤大鼠氧自由基水平的影响,以验证生态营养对胃黏膜的保护作用。方法将54只大鼠随机分为创伤对照组(I组)、肠内营养组(EN组)和生态营养组(EC组),每组各18只,建立重型颅脑损伤致急性胃黏膜损伤动物模型。EC组喂养三九全营素加贝飞达;EN组喂养三九全营素;I组喂等量生理盐水,分别于创伤喂养后第1、3、5天取标本,观察三组的胃黏膜溃疡指数(UI),检测胃黏膜丙二醛(MDA)和一氧化氮(NO)含量。每组每个时相点选6只完成测量。结果三组胃黏膜UI、MDA和NO比较,时间主效应和干预主效应差异有统计学意义(均P<0.05)。结论给重型颅脑损伤致急性胃黏膜损伤大鼠补充生态营养能减少氧自由基MDA、NO产生,从而减轻重型颅脑损伤后并发急性胃黏膜损伤的程度。
Objective To investigate the effect of ecological nutrition on the level of oxygen free radicals in rats with acute gastric mucosal injury and to verify the protective effect of ecological nutrition on gastric mucosa. Methods Fifty-four rats were randomly divided into trauma control group (I group), enteral nutrition group (EN group) and ecotrophic group (EC group), 18 rats in each group. Acute gastric mucosal injury Animal model The rats in EC group were fed with Sujia Beida Feifei. The rats in EN group were fed with Sanjiuquanpin. The rats in group I were fed with the same amount of saline. The specimens were taken on the 1st, 3rd and 5th day after trauma feeding. Mucosal ulcer index (UI), the content of malondialdehyde (MDA) and nitric oxide (NO) in gastric mucosa were detected. Select 6 for each group at each time point to complete the measurement. Results There were significant differences in the main effects of time and the intervention between the three groups of gastric mucosal UI, MDA and NO (all P <0.05). Conclusion Supplementing ecological nutrition in rats with acute gastric mucosal injury caused by severe craniocerebral injury can reduce the production of oxygen and free radicals MDA and NO and thus reduce the severity of acute gastric mucosal injury after severe craniocerebral injury.