本文研究了甲氰咪胍对正常四月龄小鼠与老年小鼠免疫功能的影响。结果表明,通过饮水给药,在100mg/kg/天的剂量下,连用14天后,四月龄小鼠脾抗体分泌细胞(PFC),特异抗原结合细胞(SRFC)及迟发型超敏反应(DTH)均明显增强。老年小鼠的PFC、SRFC、DTH均较正常四月龄小鼠低,使用甲氰咪胍后,反应也未见增强。这个结果提示,老年小鼠对甲氰咪胍的反应性与正常小鼠不同,本文对这些结果的意义进行了讨论。 This article studies the effects of cimetidine on immune function in normal and old mice. The results showed that spleen antibody secreting cells (PFCs), specific antigen-binding cells (SRFCs) and delayed-type hypersensitivity (DTH) in four-month-old mice ) Were significantly enhanced. PFC, SRFC and DTH in aged mice were lower than those in normal 4-month-old mice, and the response was not enhanced after using cimetidine. This result suggests that the reactivity of older mice to cimetidine is different from that of normal mice, and the significance of these results is discussed in this paper.