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新生儿坏死性小肠结肠炎(necrotizing enterocolitis，NEC)是新生儿期常见的胃肠道疾病，其发病率及病死率均高，目前NEC病因及发病机制尚未明确。近年来研究发现紧密连接蛋白claudins在NEC发病中起一定作用，在NEC诊断及防治中具有一定价值。研究发现claudins蛋白可作为早期辅助诊断NEC的指标，且claudins蛋白表达与NEC病变程度存在相关性。调节紧密连接蛋白claudins表达可达到防治NEC的目的。该文对紧密连接蛋白claudins及其在NEC方面应用的研究进行综述。“,”Necrotizing enterocolitis(NEC)is the most common gastrointestinal disorders in neonatal period.It has high morbidity and mortality.Its etiology and pathophysiology are still unclear.Current studies suggest that tight junction proteins of claudins contribute to the pathogenesis of NEC and may be useful in diagnosis and preventing NEC.Studies find that proteins of claudins have been identified as biomarkers for early diagnosing NEC and that expression levels of claudins correlate with severity of NEC.Recent work has showed that interventions of claudins could help preventing NEC.In this article, the tight junction proteins of claudins and its advancement in NEC are reviewed.