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用化学发光法研究镍对作业工人细胞免疫功能的影响，与非镍作业的地区对照组比较，镍作业工人外周血多形核中性粒细胞化学发光（ＰＭＮ－ＣＬ）的本底值降低（Ｐ＜０．０１），调理酵母多糖（ＯＺ）刺激诱发的ＰＭＮ－ＣＬ显著增高（Ｐ＜０．００１），＃ＦＫ提示镍对作业工人外周血ＰＭＮ－ＣＬ有不良影响．对镍作业工人补硒后，与平行对照组比较，补硒组ＰＭＮ－ＣＬ的本底值增高（Ｐ＜０．０１），受ＯＺ刺激诱发的ＰＭＮ－ＣＬ明显降低（Ｐ＜０．００１），且随补硒时间延长效果更显著，说明补硒能有效改善镍作业工人外周血ＰＭＮ－ＣＬ的异常变化；体外研究也证实了镍对ＯＺ刺激的人外周血化学发光的增强作用及硒的调节效果．
The effect of nickel on cellular immune function of workers was studied by chemiluminescence. The background value of polymorphonuclear neutrophil chemiluminescence (PMN-CL) in nickel working workers was lower than that of non-nickel control group P <0.01). PMN-CL induced by OZ stimulation was significantly increased (P <0.001), while # FK suggested that Ni had adverse effects on PMN-CL in workers exposed to OZ. Compared with the control group, the background value of PMN-CL in the selenium-enriched group increased (P <0.01) and the PMN-CL induced by OZ stimulation decreased significantly (P <0.001) , And with the effect of prolonged selenium time more significant, indicating that supplemental selenium can effectively improve the abnormal changes in peripheral blood PMN-CL workers nickel; in vitro studies also confirmed that the OZ-stimulated human peripheral blood chemiluminescence and selenium Adjust the effect.