论文部分内容阅读
目的通过临床对比选择一种治疗难治性免疫性血小板减少性紫癜的疗效确切的方法。方法将符合诊断标准的180例难治性免疫性血小板减少性紫癜患者按就诊顺序随机分为治疗组与对照组,每组90例。两组均给予泼尼松片1mg/kg.d,2次/d,口服,服用2周,然后逐渐减量维持至停用。治疗组在此基础上加用全反式维甲酸,每次10mg,每日3次,口服。两组均以4周为1个疗程,治疗1个疗程后观察疗效。结果治疗组治愈率为60.00%,对照组治愈率为40.00%,两组相比差异有统计学意义(P<0.05)。治疗组总有效率为93.33,对照组的总有效率为80.00%,两组相比差异有统计学意义(P<0.01)。CD4+CD25+T及CD4+CD25highT细胞表达水平治疗组治疗后低于对照组(P<0.01),治疗组治疗前后有明显变化(P<0.05),对照组治疗前后无明显变化(P>0.05)。治疗后治疗组血小板上升情况、有效止血时间治疗组与对照组相比差异有统计学意义(P<0.01)。结论使用全反式维甲酸治疗难治性免疫性血小板减少性紫癜可显著提高临床疗效,且具有副作用小,价格更低廉的特点。
Objective To select an effective method to treat refractory immune thrombocytopenic purpura through clinical comparison. Methods According to the order of treatment, 180 patients with immunological thrombocytopenic purpura who meet the diagnostic criteria were randomly divided into treatment group and control group, with 90 cases in each group. Both groups were given prednisone tablets 1mg / kg.d, 2 times / d, orally, taking 2 weeks, then gradually reduced to maintain use. The treatment group on this basis with the addition of all-trans retinoic acid, each 10mg, 3 times a day orally. Two groups were 4 weeks for a course of treatment, after a course of treatment observed the effect. Results The cure rate was 60.00% in the treatment group and 40.00% in the control group. There was significant difference between the two groups (P <0.05). The total effective rate was 93.33 in the treatment group and 80.00% in the control group. There was significant difference between the two groups (P <0.01). The levels of CD4 + CD25 + T and CD4 + CD25high T cells in the treatment group were lower than those in the control group (P <0.01), but there was significant difference between before and after treatment in the treatment group (P <0.05) ). The treatment group after treatment, platelet rise, effective hemostasis time treatment group compared with the control group, the difference was statistically significant (P <0.01). Conclusion The use of all-trans retinoic acid in the treatment of refractory immune thrombocytopenic purpura can significantly improve the clinical efficacy, and has the advantages of low side effects, cheaper prices.