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目的探讨肿瘤内皮标志物8(tumor endothelial marker 8,TEM8)蛋白在非小细胞肺癌(non-small cell lung cancer,NSCLC)及癌旁正常肺组织中的表达特点及其临床意义。方法采用免疫组织化学法检测110例NSCLC及30例癌旁正常肺组织中TEM8蛋白的表达,并分析TEM8表达与临床病理特征及预后的关系。结果TEM8在NSCLC中的阳性率(52.72%)明显高于癌旁正常肺组织(6.67%)(P<0.01),TEM8的表达与NSCLC的肿瘤分化程度、TNM分期(T指原发灶的情况,N指区域淋巴结受累情况,M指远处转移)和有无淋巴结转移相关(P<0.05)。Kaplan-Meier生存分析显示NSCLC中TEM8蛋白表达与患者术后总生存率呈负相关(P<0.05)。结论 TEM8高表达与NSCLC的进展和预后显著相关,可作为NSCLC患者预后判断的指标。
Objective To investigate the expression and clinical significance of tumor endothelial marker 8 (TEM8) protein in non-small cell lung cancer (NSCLC) and its adjacent normal lung tissues. Methods Immunohistochemical method was used to detect the expression of TEM8 protein in 110 NSCLC specimens and 30 adjacent normal lung tissues. The relationship between TEM8 expression and clinicopathological features and prognosis was analyzed. Results The positive rate of TEM8 in NSCLC (52.72%) was significantly higher than that in normal lung tissue (6.67%) (P <0.01). The expression of TEM8 correlated with the degree of tumor differentiation in NSCLC, TNM stage , N refers to regional lymph node involvement, M refers to distant metastasis) and lymph node metastasis (P <0.05). Kaplan-Meier survival analysis showed that the expression of TEM8 in NSCLC was negatively correlated with the overall survival (P <0.05). Conclusion The high expression of TEM8 is significantly associated with the progression and prognosis of NSCLC, which may be used as an index to predict the prognosis of NSCLC.