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采用高强度超声均质法制备由单油酸甘油酯(GMO)和Eudragit E100组成的纳米结构复合物,并采用32析因设计优化处方。回归分析结果表明,GMO和Eudragit E100的含量对粒径和包封率有极显著影响。优化后的载卡维地洛纳米结构复合物(Car-NS)粒径为(183±2.43)nm,包封率为(81.4±0.512)%。傅里叶变换红外光谱(FTIR)分析显示,卡维地洛被载入纳米结构
High-intensity ultrasound homogenization was used to prepare nanostructured composites consisting of glyceryl monooleate (GMO) and Eudragit E100, and the optimal formulation was optimized by 32 factorial design. Regression analysis showed that the contents of GMO and Eudragit E100 had a very significant effect on particle size and encapsulation efficiency. The optimized carvedilol nano-structured complex (Car-NS) particle size was (183 ± 2.43) nm, the encapsulation efficiency was (81.4 ± 0.512)%. Fourier transform infrared spectroscopy (FTIR) analysis showed that carvedilol was loaded into the nanostructures