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目的了解细胞因子IL-6、IL-10的检测在急性重症胰腺炎治疗中的作用及其对于临床的应用。方法采用法国DiaClone公司提供的试剂盒用固相免疫吸附法检测21例SAP患者在治疗前后的血清中的IL-6和IL-10的变化。结果21例SAP患者的细胞因子IL-6和IL-10治疗前与治疗后相比具有显著差异(P〈0.05〉。结论由上述结果可知IL-6和IL-10均可作为监测重症胰腺炎的重要指标,动态监测有助于SAP病情的判断,降低SAP及其并发症的死亡率。
Objective To investigate the role of cytokines IL-6 and IL-10 in the treatment of acute severe pancreatitis and its clinical application. Methods Serum levels of IL-6 and IL-10 in 21 patients with SAP were measured by solid-phase immunosorbent assay (ELISA) using the kit supplied by DiaClone, France. Results The levels of IL-6 and IL-10 in 21 patients with SAP were significantly different from those before treatment (P <0.05) .Conclusion IL-6 and IL-10 can be used as indicators for monitoring severe pancreatitis Of the important indicators, dynamic monitoring contribute to the judgment of SAP’s condition, reduce the mortality rate of SAP and its complications.