论文部分内容阅读
目的探讨侵犯颅底的头颈部恶性肿瘤的预后相关因素。方法1997年1月～2005年12月收治的24例侵犯颅底的头颈部恶性肿瘤患者,采用手术为主、结合放化疗的综合治疗方案。应用Kaplan-Meier法计算累积生存率,并以Cox回归模型进行预后的多因素分析。结果全组患者3、5年生存率分别为71.3%、62.1%;年龄(P=0.0273)、侵犯颅底解剖区域(P=0.0001)、病理分级(P=0.0251)及有无复发(P=0.0011)均是影响预后的单项危险因素;多因素分析显示,仅有侵犯颅底解剖区域(P=0.0118)是影响预后的独立因素。结论侵犯颅底的头颈部恶性肿瘤患者,所侵犯的颅底解剖区域对预后有重要意义,同时有前、侧颅底侵犯者预后较差。
Objective To investigate the prognostic factors of head and neck malignant tumors in the skull base. Methods From January 1997 to December 2005, 24 cases of head and neck malignant tumor which had been infiltrated the skull base were treated with operation and combined with radiotherapy and chemotherapy. The cumulative survival rate was calculated using Kaplan-Meier method and multivariate analysis of prognosis was performed by Cox regression model. Results The 3-year and 5-year survival rates of all patients were 71.3% and 62.1% respectively. The age (P = 0.0273), invasion of skull base anatomy area (P = 0.0001), pathological grade 0.0011) were all risk factors influencing prognosis. Multivariate analysis showed that only infringement of skull base anatomy (P = 0.0118) was an independent prognostic factor. Conclusion In patients with head and neck malignant tumor who infiltrated the skull base, the infiltrated skull base anatomy area is of great significance to prognosis. Meanwhile, the prognosis of anterior and lateral skull base invaders is poor.